Locust: C++ software for simulation of RF detection

The Locust simulation package is a newC++software tool developed to simulate the measurement of time-varying electromagnetic fields using RF detection techniques. Modularity and flexibility allow for arbitrary input signals, while concurrently supporting tight integration with physics-based simulations as input. External signals driven by the Kassiopeia particle tracking package are discussed, demonstrating conditional feedback between Locust and Kassiopeia during software execution. An application of the simulation to the Project8 experiment is described

Cancer Biomarker Discovery: The Entropic Hallmark

Background: It is a commonly accepted belief that cancer cells modify their transcriptional state during the progression of the disease. We propose that the progression of cancer cells towards malignant phenotypes can be efficiently tracked using high-throughput technologies that follow the gradual changes observed in the gene expression profiles by employing Shannon's mathematical theory of communication. Methods based on Information Theory can then quantify the divergence of cancer cells' transcriptional profiles from those of normally appearing cells of the originating tissues. The relevance of the proposed methods can be evaluated using microarray datasets available in the public domain but the method is in principle applicable to other high-throughput methods. Methodology/Principal Findings: Using melanoma and prostate cancer datasets we illustrate how it is possible to employ Shannon Entropy and the Jensen-Shannon divergence to trace the transcriptional changes progression of the disease. We establish how the variations of these two measures correlate with established biomarkers of cancer progression. The Information Theory measures allow us to identify novel biomarkers for both progressive and relatively more sudden transcriptional changes leading to malignant phenotypes. At the same time, the methodology was able to validate a large number of genes and processes that seem to be implicated in the progression of melanoma and prostate cancer. Conclusions/Significance: We thus present a quantitative guiding rule, a new unifying hallmark of cancer: the cancer cell's transcriptome changes lead to measurable observed transitions of Normalized Shannon Entropy values (as measured by high-throughput technologies). At the same time, tumor cells increment their divergence from the normal tissue profile increasing their disorder via creation of states that we might not directly measure. This unifying hallmark allows, via the the Jensen-Shannon divergence, to identify the arrow of time of the processes from the gene expression profiles, and helps to map the phenotypical and molecular hallmarks of specific cancer subtypes. The deep mathematical basis of the approach allows us to suggest that this principle is, hopefully, of general applicability for other diseases

Synergy between cosmological and laboratory searches in neutrino physics

The intersection of the cosmic and neutrino frontiers is a rich field where much discovery space still remains. Neutrinos play a pivotal role in the hot big bang cosmology, influencing the dynamics of the universe over numerous decades in cosmological history. Recent studies have made tremendous progress in understanding some properties of cosmological neutrinos, primarily their energy density. Upcoming cosmological probes will measure the energy density of relativistic particles with higher precision, but could also start probing other properties of the neutrino spectra. When convolved with results from terrestrial experiments, cosmology can become even more acute at probing new physics related to neutrinos or even Beyond the Standard Model (BSM). Any discordance between laboratory and cosmological data sets may reveal new BSM physics and/or suggest alternative models of cosmology. We give examples of the intersection between terrestrial and cosmological probes in the neutrino sector, and briefly discuss the possibilities of what different laboratory experiments may see in conjunction with cosmological observatories.The intersection of the cosmic and neutrino frontiers is a rich field where much discovery space still remains. Neutrinos play a pivotal role in the hot big bang cosmology, influencing the dynamics of the universe over numerous decades in cosmological history. Recent studies have made tremendous progress in understanding some properties of cosmological neutrinos, primarily their energy density. Upcoming cosmological probes will give higher precision on the energy density, but could also start probing other properties of the neutrino spectra. When convolved with results from terrestrial experiments, cosmology can become even more acute at probing new physics related to neutrinos or even Beyond the Standard Model (BSM). Any discordance between laboratory and cosmological data sets may reveal new BSM physics or suggest alternative models of cosmology. We give examples of the intersection between terrestrial and cosmological probes in the neutrino sector, and briefly discuss the possibilities of what different experiments may see in conjunction with cosmological observatories

Determining the neutrino mass with cyclotron radiation emission spectroscopy—Project 8

The most sensitive direct method to establish the absolute neutrino mass is observation of the endpoint of the tritium beta-decay spectrum. Cyclotron radiation emission spectroscopy (CRES) is a precision spectrographic technique that can probe much of the unexplored neutrino mass range with O(eV) resolution. A lower bound of m(νe) ≳ 9(0.1) meV is set by observations of neutrino oscillations, while the KATRIN experiment-the current-generation tritium beta-decay experiment that is based on magnetic adiabatic collimation with an electrostatic (MAC-E) filter-will achieve a sensitivity of m(νe) ≲ 0.2 eV. The CRES technique aims to avoid the difficulties in scaling up a MAC-E filter-based experiment to achieve a lower mass sensitivity. In this paper we review the current status of the CRES technique and describe Project 8, a phased absolute neutrino mass experiment that has the potential to reach sensitivities down to m(νe) ≲ 40 meV using an atomic tritium source.United States. Department of Energy (Grant DE-SC0011091